Coyote mint is a good source of both pollen and nectar for native bees and bumblebees. It is also a nectar source for hummingbirds and butterflies. Butterflies seen on coyote mint include monarch, chalcedon checkerspot, ruddy copper, rural skipper, pale swallowtail and Western tiger swallowtail.

This plant is used by the Indigenous peoples of California as a remedy for stomach upset, respiratory conditions, and sore throat. It may also be steeped into a bitter mint tea. It smells like a minty toothpaste.